VU0455691
VU0455691 is a potent, selective orthosteric M1 mAChR antagonist (pIC50=6.64; IC50=0.23 µM for hM1) [1].
Product Specifications
CAS Number
1392443-41-2
UNSPSC
12352005
Target
MAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/vu0455691.html
Solubility
10 mM in DMSO
Smiles
O=C(C1CN(C1)S(=O)(C2=CC=CC3=C2C=CN=C3)=O)N4CC5CN(CC5C4)C6=CC=NC=C6
Molecular Formula
C24H25N5O3S
Molecular Weight
463.55
References & Citations
[1]Melancon BJ, et al. Development of novel M1 antagonist scaffolds through the continued optimization of the MLPCN probe ML012. Bioorg Med Chem Lett. 2012;22 (15) :5035-5040.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MAChR1
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