GCA-186
GCA-186 is a potent anti-HIV-1 agent. GCA-186 is highly active against both wild type and mutated HIV-1 strains with EC50s of 1, 180, 1, and 40 nM for IIIB, IIIB-R (Y181C), NL4-3 and NL4-3K103N of HIV-1 strains, respectively[1].
Product Specifications
CAS Number
149950-61-8
UNSPSC
12352005
Target
HIV
Type
Reference compound
Related Pathways
Anti-infection
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/gca-186.html
Solubility
10 mM in DMSO
Smiles
O=C1NC(C(C(C)C)=C(N1COCC)CC2=CC(C)=CC(C)=C2)=O
Molecular Formula
C19H26N2O3
Molecular Weight
330.42
References & Citations
[1]El-Brollosy NR, et al. Synthesis and antiviral evaluation of 6- (trifluoromethylbenzyl) and 6- (fluorobenzyl) analogues of HIV drugs emivirine and GCA-186. Arch Pharm (Weinheim) . 2008;341 (1) :9-19. |[2]Hopkins AL, et al. Design of MKC-442 (emivirine) analogues with improved activity against drug-resistant HIV mutants. J Med Chem. 1999;42 (22) :4500-4505.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HIV-1
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