Trans-Cevimeline (hydrochloride)

Trans-Cevimeline (AF102A) (hydrochloride), as a trans-isomer of AF102B, is a M1 selective cholinergic agonist. Trans-Cevimeline (AF102A) (hydrochloride) can be used for the research of Alzheimer's disease[1].

Product Specifications

CAS Number

[107220-29-1]

Product Name Alternative

AF102A (hydrochloride)

UNSPSC

12352005

Hazard Statement

H301-H332-H351-H361

Target

MAChR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/trans-cevimeline-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

C[C@@H]1SC[C@@]2(CN3CCC2CC3)O1.[H]Cl

Molecular Formula

C10H18ClNOS

Molecular Weight

235.77

Precautions

P261-P264-P270-P271-P280-P304+P340-P330-P405-P501

References & Citations

[1]Fisher A, et al. (+-) -cis-2-methyl-spiro (1,3-oxathiolane-5,3') quinuclidine, an M1 selective cholinergic agonist, attenuates cognitive dysfunctions in an animal model of Alzheimer's disease. J Pharmacol Exp Ther. 1991;257 (1) :392-403.