Propanidid

Propanidid (Sombrevin; Fabantol) is a γ-aminobutyric acid type A (GABAA) receptor agonist and a short-acting non-barbiturate general agent that can suppress or relieve pain. Propanidid can decrease the arterial pressure[1][2].

Product Specifications

CAS Number

[1421-14-3]

Product Name Alternative

Sombrevin; Fabantol

UNSPSC

12352005

Target

GABA Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/propanidid.html

Purity

98.19

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(CC1=CC=C(C(OC)=C1)OCC(N(CC)CC)=O)OCCC

Molecular Formula

C18H27NO5

Molecular Weight

337.41

References & Citations

[1]Cenani A, et al. In vitro and in vivo GABAA Receptor Interaction of the Propanidid Metabolite 4- (2-[Diethylamino]-2-Oxoethoxy) -3-Methoxy-Benzeneacetic Acid. Pharmacology. 2019;103 (1-2) :10-16.|[2]Orko R. Anaesthesia for cardioversion: a comparison of diazepam, thiopentone and propanidid. Br J Anaesth. 1976 Mar;48 (3) :257-62.|[3]Lazareva NA, et al. The effect of sombrevin on the orientation adjustment of the visual cortex neurons in the cat. Neirofiziologiia. 1989;21 (6) :812-20.