4α-Phorbol 12,13-didecanoate

4α-Phorbol 12,13-didecanoate (4αPDD) is a transient receptor potential vanilloid 4 (TRPV4) agonist. 4α-Phorbol 12,13-didecanoate can promote Ca2+ influx, induce ATP release and function as an osmoreceptor. 4α-Phorbol 12,13-didecanoate can inhibit water intake and increase maximal micturition pressure in rats. 4α-Phorbol 12,13-didecanoate can be used for the researches of inflammation and infection, such as chikungunya virus (CHIKV) [1][2][3][4].

Product Specifications

CAS Number

[27536-56-7]

Product Name Alternative

4αPDD

UNSPSC

12352211

Hazard Statement

H300+H310+H330, H314, H317, H334, H351

Target

CHIKV; TRP Channel

Type

Reference compound

Related Pathways

Anti-infection; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/4α-phorbol-12-13-didecanoate.html

Purity

99.30

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CCCCCCCCCC(O[C@@]12[C@@]([C@@]3([H])[C@]([C@@H]([C@H]2OC(CCCCCCCCC)=O)C)([C@@]4([H])[C@@](CC(CO)=C3)(C(C(C)=C4)=O)O)O)([H])C1(C)C)=O

Molecular Formula

C40H64O8

Molecular Weight

672.93

Precautions

H300+H310+H330, H314, H317, H334, H351

References & Citations

[1]Hiromi Tsushima, et al. Antidipsogenic effects of a TRPV4 agonist, 4alpha-phorbol 12,13-didecanoate, injected into the cerebroventricle. Am J Physiol Regul Integr Comp Physiol. 2006 Jun;290 (6) :R1736-41.|[2]Lori Birder, et al. Activation of urothelial transient receptor potential vanilloid 4 by 4alpha-phorbol 12,13-didecanoate contributes to altered bladder reflexes in the rat. J Pharmacol Exp Ther. 2007 Oct;323 (1) :227-35. |[3]Alexander R, et al. 4α-phorbol 12,13-didecanoate activates cultured mouse dorsal root ganglia neurons independently of TRPV4. Br J Pharmacol. 2013 Feb;168 (3) :761-72.|[4]Nothias-Scaglia LF, et al. Antiviral Activity of Diterpene Esters on Chikungunya Virus and HIV Replication. J Nat Prod. 2015 Jun 26;78 (6) :1277-83.