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4α-Phorbol 12,13-didecanoate

Product Specifications

UNSPSC Description

4α-Phorbol 12,13-didecanoate (4αPDD) is a TRPV4 agonist with antidipsogenic effects. 4α-Phorbol 12,13-didecanoate promotes Ca2+ influx[1].

Target Antigen

TRP Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel;Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/4α-phorbol-12-13-didecanoate.html

Purity

99.30

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CCCCCCCCCC(O[C@@]12[C@@]([C@@]3([H])[C@]([C@@H]([C@H]2OC(CCCCCCCCC)=O)C)([C@@]4([H])[C@@](CC(CO)=C3)(C(C(C)=C4)=O)O)O)([H])C1(C)C)=O

Molecular Weight

672.93

References & Citations

[1]Hiromi Tsushima, et al. Antidipsogenic effects of a TRPV4 agonist, 4alpha-phorbol 12,13-didecanoate, injected into the cerebroventricle. Am J Physiol Regul Integr Comp Physiol. 2006 Jun;290(6):R1736-41.|[2]Lori Birder, et al. Activation of urothelial transient receptor potential vanilloid 4 by 4alpha-phorbol 12,13-didecanoate contributes to altered bladder reflexes in the rat. J Pharmacol Exp Ther. 2007 Oct;323(1):227-35.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-116291/4α-Phorbol-12-13-didecanoate-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-116291/4α-Phorbol-12-13-didecanoate-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

27536-56-7

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