Zaragozic acid A

Zaragozic acid A is a fungal metabolite that acts as a reversible competitive inhibitor of squalene synthase. Zaragozic acid A is an inhibitor of acute hepatic cholesterol synthesis in mouse (IC50 = 6 μM) [1].

Product Specifications

CAS Number

[142561-96-4]

Product Name Alternative

Squalestatin S1

UNSPSC

12352005

Target

Endogenous Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/zaragozic-acid-a.html

Purity

99.2

Solubility

H2O : 1 mg/mL (ultrasonic; warming)

Smiles

CC[C@@H](C[C@@H](/C=C/C(O[C@@H]1[C@H]([C@]2(O[C@@H]([C@@](C(O)=O)([C@]1(C(O)=O)O2)O)C(O)=O)CCC([C@H]([C@@H](CC3=CC=CC=C3)C)OC(C)=O)=C)O)=O)C)C

Molecular Formula

C35H46O14

Molecular Weight

690.73

References & Citations

[1]J D Bergstrom, et al. Zaragozic acids: a family of fungal metabolites that are picomolar competitive inhibitors of squalene synthase. Proc Natl Acad Sci U S A. 1993 Jan 1;90 (1) :80-4.