ROCK-IN-D2

ROCK-IN-D2 is a potent and selective ROCK inhibitor[1].

Product Specifications

CAS Number

[1219721-78-4]

UNSPSC

12352005

Target

ROCK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt; TGF-beta/Smad

Applications

Cancer-Kinase/protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/rock-in-d2.html

Solubility

10 mM in DMSO

Smiles

O=C(NCC1=CC=CC=C1)NC2=C(C=C(C=C2)C3=CNN=C3)N(C)CCN(C)C

Molecular Formula

C22H28N6O

Molecular Weight

392.50

References & Citations

[1]Ding Mei, et al. Discovery of potent and selective urea-based ROCK inhibitors: Exploring the inhibitor’s potency and ROCK2/PKA selectivity by 3D-QSAR, molecular docking and molecular dynamics simulations.Bioorg Med Chem. 2015 May 15;23 (10) :2505-17.