(2S,3R) -LP99

(2S,3R) -LP99 is a potent and selective BRD7 and BRD9 inhibitor with an KD of 99 nM for BRD9. (2S,3R) -LP99 inhibits the association of BRD7 and BRD9 to acetylated histones in vitro and in cells. (2S,3R) -LP99 demonstrates that BRD7/9 plays a role in regulating pro-inflammatory cytokine secretion[1].

Product Specifications

CAS Number

[1808948-28-8]

UNSPSC

12352005

Target

Epigenetic Reader Domain

Type

Reference compound

Related Pathways

Epigenetics

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/2s-3r-lp99.html

Purity

99.4

Solubility

10 mM in DMSO

Smiles

CC(CS(=O)(N[C@@H]([C@@H](N1C2=CC3=C(C(C)=CC(N3C)=O)C=C2)C4=CC=C(C=C4)Cl)CCC1=O)=O)C

Molecular Formula

C26H30ClN3O4S

Molecular Weight

516.05

References & Citations

[1]Clark PG, et al. LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor. Angew Chem Int Ed Engl. 2015 May 18;54 (21) :6217-21.