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YQA14

YQA14 is a high affinity dopamine D3 receptor antagonist. YQA14 is anti-opioid addiction agent. YQA14 inhibits Morphine/Cocaine-induced conditioned place preference (CPP) in animals[1][2].

Product Specifications

CAS Number

1221408-42-9

UNSPSC

12352005

Target

Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/yqa14.html

Purity

98.62

Solubility

10 mM in DMSO

Smiles

O=C(NCCCCN1CCN(CC1)C2=CC(Cl)=CC=C2C)C3=CC=C4OC(NC4=C3)=O

Molecular Formula

C23H27ClN4O3

Molecular Weight

442.94

References & Citations

[1]Hu R, et al. The dopamine D3 receptor antagonist YQA14 that inhibits the expression and drug-primed reactivation of morphine-induced conditioned place preference in rats. Eur J Pharmacol. 2013 Oct 24:S0014-2999 (13) 00782-6.|[2]Song R, et al. Dopamine D (3) receptor deletion or blockade attenuates cocaine-induced conditioned place preference in mice. Neuropharmacology. 2013 Sep;72:82-7.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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