YQA14
YQA14 is a high affinity dopamine D3 receptor antagonist. YQA14 is anti-opioid addiction agent. YQA14 inhibits Morphine/Cocaine-induced conditioned place preference (CPP) in animals[1][2].
Product Specifications
CAS Number
[1221408-42-9]
UNSPSC
12352005
Target
Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/yqa14.html
Purity
98.62
Solubility
10 mM in DMSO
Smiles
O=C(NCCCCN1CCN(CC1)C2=CC(Cl)=CC=C2C)C3=CC=C4OC(NC4=C3)=O
Molecular Formula
C23H27ClN4O3
Molecular Weight
442.94
References & Citations
[1]Hu R, et al. The dopamine D3 receptor antagonist YQA14 that inhibits the expression and drug-primed reactivation of morphine-induced conditioned place preference in rats. Eur J Pharmacol. 2013 Oct 24:S0014-2999 (13) 00782-6.|[2]Song R, et al. Dopamine D (3) receptor deletion or blockade attenuates cocaine-induced conditioned place preference in mice. Neuropharmacology. 2013 Sep;72:82-7.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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