ER-819762

ER-819762 is an orally active, highly selective prostaglandin E2 (PGE2) EP4 receptor antagonist with an EC50 of 70 nM against human EP4 receptor. ER-819762 can be used for rheumatoid arthritis research[1].

Product Specifications

CAS Number

1155773-15-1

UNSPSC

12352005

Target

Prostaglandin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/er-819762.html

Solubility

10 mM in DMSO

Smiles

CCN1C2(CCN(CC2)CC3=CC(C)=CC(C)=C3)C(N(CC4=CC(OC)=C5)C1=O)=C[C@H](C)C4=C5OC

Molecular Formula

C30H39N3O3

Molecular Weight

489.65

References & Citations

[1]Chen Q, et al. A novel antagonist of the prostaglandin E (2) EP (4) receptor inhibits Th1 differentiation and Th17 expansion and is orally active in arthritis models. Br J Pharmacol. 2010 May;160 (2) :292-310.