VU0404251
VU0404251 is a highly potent positive allosteric modulator of mGlu for the study of psychosis[1].
Product Specifications
CAS Number
1276013-77-4
UNSPSC
12352005
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/vu0404251.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@H](C)C(C)(C)C)C1=CC=C(N=C1)OCC2=CC=CC(F)=C2
Molecular Formula
C19H23FN2O2
Molecular Weight
330.40
References & Citations
[1]Manka JT, et al. Optimization of an ether series of mGlu5 positive allosteric modulators: molecular determinants of MPEP-site interaction crossover. Bioorg Med Chem Lett. 2012 Oct 15;22 (20) :6481-5.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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