Epiroprim

Epiroprim (Ro11-8958) is a selective dihydrofolate reductase (DHFR) inhibitor. Epiroprim displays excellent activity against staphylococci, enterococci, pneumococci, and streptococci[1].

Product Specifications

CAS Number

73090-70-7

Product Name Alternative

Ro11-8958

UNSPSC

12352005

Target

Bacterial; Dihydrofolate reductase (DHFR)

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/epiroprim.html

Solubility

10 mM in DMSO

Smiles

CCOC1=C(C(OCC)=CC(CC2=CN=C(N=C2N)N)=C1)N3C=CC=C3

Molecular Formula

C19H23N5O2

Molecular Weight

353.42

References & Citations

[1]H H Locher, et al. Antibacterial activities of epiroprim, a new dihydrofolate reductase inhibitor, alone and in combination with dapsone. Antimicrob Agents Chemother. 1996 Jun;40 (6) :1376-81.