12,13-DiHOME

12,13-DiHOME is a stimulator of Brown adipose tissue (BAT), as well as a thermogenic lipokine that activates BAT in response to cold. (±) 12,13-DiHOME activates BAT fuel uptake and enhances cold tolerance, via promoting the translocation of the FA transporters FATP1 and CD36 to the cell membrane. (±) 12,13-DiHOME can be used for research of metabolic disorders[1].

Product Specifications

CAS Number

[263399-35-5]

UNSPSC

12352211

Hazard Statement

H225, H319, H336

Target

Endogenous Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/12-13-dihome.html

Concentration

318.01 μM * 5 mL in Methyl acetate

Purity

99.5

Solubility

10 mM in DMSO

Smiles

CCCCCC(C(C/C=C\CCCCCCCC(O)=O)O)O

Molecular Formula

C18H34O4

Molecular Weight

314.46

Precautions

H225, H319, H336

References & Citations

[1]Lynes MD, et al. The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue. Nat Med. 2017 May;23 (5) :631-637.