Carbonic anhydrase inhibitor 10

Carbonic anhydrase inhibitor 10 is a potent hCA IX inhibitor with a Ki value of 6.2 nM. Carbonic anhydrase inhibitor 10 exhibits anti-proliferative activity against MCF-7 cancer cell line with an IC50 of 11.9 μM. Carbonic anhydrase inhibitor 10 can be used for cancer research[1].

Product Specifications

CAS Number

[2883453-30-1]

UNSPSC

12352005

Target

Carbonic Anhydrase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/carbonic-anhydrase-inhibitor-10.html

Solubility

10 mM in DMSO

Smiles

CC1=NC(C)=C(N=C1NC(NC2=CC=C(C=C2)S(N)(=O)=O)=O)C

Molecular Formula

C14H17N5O3S

Molecular Weight

335.38

References & Citations

[1]Diaaeldin M Elimam, et al. Natural inspired ligustrazine-based SLC-0111 analogues as novel carbonic anhydrase inhibitors. Eur J Med Chem. 2022 Jan 15;228:114008.