CDK4/6-IN-10
Product Specifications
UNSPSC Description
CDK4/6-IN-10 is a potent, selective and orally active CDK4 and CDK6 inhibitor with IC50s of 22 nM and 10 nM, respectively. CDK4/6-IN-10 shows antitumor activity. CDK4/6-IN-10 has the potential for the research of Multiple myeloma (MM)[1].
Target Antigen
Apoptosis; CDK
Type
Reference compound
Related Pathways
Apoptosis;Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cdk4-6-in-10.html
Solubility
10 mM in DMSO
Smiles
CN1C=C(C2=NC(NC3=NC=C(CN4CCNCC4)C=C3)=NC=C2F)C5=CC=CN=C51
Molecular Weight
418.47
References & Citations
[1]Yuan K, et al. Discovery of novel and orally bioavailable CDK 4/6 inhibitors with high kinome selectivity, low toxicity and long-acting stability for the treatment of multiple myeloma. Eur J Med Chem. 2022; 228:114024.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-115993/CDK4-6-IN-10-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-115993/
Clinical Information
No Development Reported
CAS Number
2688098-11-3
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
![Rabbit Monoclonal Complement Component C5aR1 Antibody (S5/1) [DyLight 488]](https://cdn.genprice.uk/genprice/genprice3.png)
NBP3-12083G 0.1 mL
Rabbit Monoclonal Complement Component C5aR1 Antibody (S5/1) [DyLight 488]
Ask
View Details 