Aldose reductase-IN-3
Aldose reductase-IN-3 (Compound 5) is a potent and moderately selective inhibitor of aldose reductase (AR) with an IC50 of 3.99 μM. Aldose reductase has recently emerged as a molecular target that is involved in various inflammatory diseases, including sepsis. Aldose reductase-IN-3 has the potential for the research of sepsis[1].
Product Specifications
CAS Number
1390616-76-8
UNSPSC
12352005
Target
Aldose Reductase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/aldose-reductase-in-3.html
Solubility
10 mM in DMSO
Smiles
O=C1N=C(NC2=NC3=CC=C(OC)C=C3S2)S/C1=C\C4=CC=C(Cl)C=C4
Molecular Formula
C18H12ClN3O2S2
Molecular Weight
401.89
References & Citations
[1]Kousaxidis A, et al. Non-acidic bifunctional benzothiazole-based thiazolidinones with antimicrobial and aldose reductase inhibitory activity as a promising therapeutic strategy for sepsis [published online ahead of print, 2021 Aug 4]. Med Chem Res. 2021;1-12.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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