COX-2-IN-10
Product Specifications
UNSPSC Description
COX-2-IN-10 is a potent COX-2 inhibitor. COX-2-IN-10 inhibits the production of PGE2 in concentration dependent manner (IC50=2.54 μM). COX-2-IN-10 inhibits the expression of iNOS and COX-2 on mRNA and protein level . COX-2-IN-10 inhibits the production of IL-6, TNF-α and IL-1β[1].
Target Antigen
COX
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cox-2-in-10.html
Solubility
10 mM in DMSO
Smiles
CC(C)(N1C=C(C(C2=CC(F)=CC=C2)=N1)C3=CC=NC(NCCCNS(=O)(C4=CC5=C(C=C4)C=CC=C5)=O)=C3)C
Molecular Weight
557.68
References & Citations
[1]Karim I. M, et al. Design, synthesis, in vitro determination and molecular docking studies of 4-(1-(tert-butyl)-3-phenyl-1H-pyrazol-4-yl) pyridine derivatives with terminal sulfonamide derivatives in LPS-induced RAW264.7 macrophage cells. Medicinal Chemistry Research, 2021, 30: 1925-1942.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-115976/COX-2-IN-10-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-115976/
Clinical Information
No Development Reported
Curated Selection
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