GRPR antagonist-2

GRPR antagonist-2 is a potent gastrin releasing peptide receptor (GRPR) antagonist, having the cytotoxicity against certain cancer cells (IC50 of 0.77 and 2.5 μM in HGC-27 and Pan02 cells, respectively) . Anticancer activity[1].

Product Specifications

CAS Number

[3052544-42-7]

UNSPSC

12352005

Target

Bombesin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/grpr-antagonist-2.html

Solubility

10 mM in DMSO

Smiles

CC(C)(OC(N1CCN(CC1)C([C@H](CC2=CNC3=C2C=CC=C3)NC(NC4=CC=C(C=C4)C(F)(F)F)=O)=O)=O)C

Molecular Formula

C28H32F3N5O4

Molecular Weight

559.58

References & Citations

[1]Yu, Mj., et al. Structure–activity relationship studies on Pd176252 derivatives leading to discovery of novel GRP receptor antagonist with potent anticancer activity. Med Chem Res 30, 2069–2089 (2021) .