COX-1/2-IN-2

COX-1/2-IN-2 is a potent COX1/2 inhibitor. COX-1/2-IN-2 exhibits significant inhibitory effect against COX-1 and COX-2 inhibitor with IC50 values of 9.7 ± 0.09 µM and 4.6 ± 1.45 µM, respectively[1].

Product Specifications

CAS Number

[2882832-86-0]

UNSPSC

12352005

Target

COX

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/cox-1-2-in-2.html

Solubility

10 mM in DMSO

Smiles

CC1=[N+](C(C2=CC=C(C=C2)Cl)=NC3=CC=C(C=C31)I)[O-]

Molecular Formula

C15H10ClIN2O

Molecular Weight

396.61

References & Citations

[1]Malose J. Mphahlele, et al. Synthesis, in vitro and in silico enzyme (COX-1/2 & LOX-5), free radical scavenging and cytotoxicity profiling of the 2,4-dicarbo substituted quinazoline 3-oxides. Medicinal Chemistry Research volume 31, pages146–164 (2022)