EGFR/HER2-IN-2

EGFR/HER2-IN-2 (Compound ZINC35560729) is a dual inhibitor of EGFR and HER2 with IC50 values of 5.02 µM and 0.83 µM against EGFR and HER2, respectively[1].

Product Specifications

CAS Number

[1215571-02-0]

UNSPSC

12352005

Target

EGFR

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/egfr-her2-in-2.html

Solubility

10 mM in DMSO

Smiles

COC1=CC=C(C2=NN=C(C3=NC(NCC4=CC=CC=C4OCC)=C5C=CC=CC5=N3)O2)C=C1

Molecular Formula

C26H23N5O3

Molecular Weight

453.49

References & Citations

[1]Sangande, et al. 2-substituted 4-aminoquinazoline derivatives as potential dual inhibitors of EGFR and HER2: an in silico and in vitro study. Medicinal Chemistry Research 31.5 (2022) : 762-771.