EGFR/HER2-IN-2
Product Specifications
UNSPSC Description
EGFR/HER2-IN-2 (Compound ZINC35560729) is a dual inhibitor of EGFR and HER2 with IC50 values of 5.02 µM and 0.83 µM against EGFR and HER2, respectively[1].
Target Antigen
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-her2-in-2.html
Solubility
10 mM in DMSO
Smiles
COC1=CC=C(C2=NN=C(C3=NC(NCC4=CC=CC=C4OCC)=C5C=CC=CC5=N3)O2)C=C1
Molecular Weight
453.49
References & Citations
[1]Sangande, et al. 2-substituted 4-aminoquinazoline derivatives as potential dual inhibitors of EGFR and HER2: an in silico and in vitro study. Medicinal Chemistry Research 31.5 (2022): 762-771.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-115951/EGFR-HER2-IN-2-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-115951/
Clinical Information
No Development Reported
CAS Number
1215571-02-0
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