Anticancer agent 29
Anticancer agent 29 (Compd E/Z-6f) is an anticancer agent, with IC50 values of 0.054 μM, 0.127 μM, 0.129 μM, 0.396 μM for CDK2, CDK1, CDK4 and CDK6, respectively[1].
Product Specifications
CAS Number
2907774-89-2
UNSPSC
12352005
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/anticancer-agent-29.html
Solubility
10 mM in DMSO
Smiles
O=C1/C(C2=CC=CC=C2N1CC3=CC=C(C=C3)F)=C/C4=CC=C(C=C4)Cl
Molecular Formula
C22H15ClFNO
Molecular Weight
363.81
References & Citations
[1]Hend A A Abd El-Wahab, et al. New cell cycle checkpoint pathways regulators with 2-Oxo-indoline scaffold as potential anticancer agents: Design, synthesis, biological activities and in silico studies. Bioorg Chem. 2022 Jan 15;120:105622.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK1; CDK2; CDK4; CDK6
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