Urease-IN-2
Urease-IN-2 (compound 8g) is a non-competitive urease inhibitor with an IC50 of 0.94 μM and a Ki of 1.6 μM. Urease-IN-2 inhibits the Jack bean urease (JBU) in a non-competitive manner[1].
Product Specifications
UNSPSC
12352005
Target
Bacterial; Urease
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/urease-in-2.html
Solubility
10 mM in DMSO
Smiles
O=C(C(N(C1=CC=CC=C1)C(CSC2=NN=C(S2)C3=CC=C(O3)[N+]([O-])=O)=O)C4=CC=CS4)NC5CCCCC5
Molecular Formula
C26H25N5O5S3
Molecular Weight
583.70
References & Citations
[1]Mehdi Asadi, et al. Synthesis and in vitro urease inhibitory activity of 5-nitrofuran-2-yl-thiadiazole linked to different cyclohexyl-2- (phenylamino) acetamides, in silico and kinetic studies. Bioorg Chem. 2022 Jan 17;120:105592.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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