COX-2-IN-8
COX-2-IN-8 (compound 6a) is a potent, selective, and orally active inhibitor of COX-2 with an IC50 of 6.585 uM. COX-2-IN-8 has higher COX-2 selectivity than Celecoxib. COX-2-IN-8 shows good in vivo anti-inflammatory and low ulcerogenic activity[1].
Product Specifications
UNSPSC
12352005
Target
COX
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cox-2-in-8.html
Solubility
10 mM in DMSO
Smiles
CCOC(CSC1=NN(C(C2=CC=CC=C2)=N1)C3=CC=C(C=C3)S(C)(=O)=O)=O
Molecular Formula
C19H19N3O4S2
Molecular Weight
417.50
References & Citations
[1]Abdellatif KRA, et al. Design, synthesis, and pharmacological evaluation of novel and selective COX-2 inhibitors based on celecoxib scaffold supported with in vivo anti-inflammatory activity, ulcerogenic liability, ADME profiling and docking study [published online ahead of print, 2022 Jan 19]. Bioorg Chem. 2022;120:105627.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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