COX-2-IN-8

COX-2-IN-8 (compound 6a) is a potent, selective, and orally active inhibitor of COX-2 with an IC50 of 6.585 uM. COX-2-IN-8 has higher COX-2 selectivity than Celecoxib. COX-2-IN-8 shows good in vivo anti-inflammatory and low ulcerogenic activity[1].

Product Specifications

UNSPSC

12352005

Target

COX

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/cox-2-in-8.html

Solubility

10 mM in DMSO

Smiles

CCOC(CSC1=NN(C(C2=CC=CC=C2)=N1)C3=CC=C(C=C3)S(C)(=O)=O)=O

Molecular Formula

C19H19N3O4S2

Molecular Weight

417.50

References & Citations

[1]Abdellatif KRA, et al. Design, synthesis, and pharmacological evaluation of novel and selective COX-2 inhibitors based on celecoxib scaffold supported with in vivo anti-inflammatory activity, ulcerogenic liability, ADME profiling and docking study [published online ahead of print, 2022 Jan 19]. Bioorg Chem. 2022;120:105627.