EGFR/BRAF-IN-1
EGFR/BRAF-IN-1 (compound 21), a 2,3-dihydropyrazino[1,2-a]indole-1,4-dione derivative, is a potent EGFR/BRAF inhibitor with an IC50 of 45 nM for BRAFV600E. EGFR/BRAF-IN-1 inhibits cancer cell proliferation (GI50=35 nM) . EGFR/BRAF-IN-1 shows good antioxidant activity[1].
Product Specifications
CAS Number
2906174-89-6
UNSPSC
12352005
Target
EGFR; Raf
Type
Reference compound
Related Pathways
JAK/STAT Signaling; MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-braf-in-1.html
Solubility
10 mM in DMSO
Smiles
CCOCC1=C2C(N(CC(N2C3=CC=C(C=C31)Cl)=O)CCC4=CC=C(C=C4)N5CCOCC5)=O
Molecular Formula
C26H28ClN3O4
Molecular Weight
481.97
References & Citations
[1]Hesham A M Gomaa, et al.Optimization and SAR investigation of novel 2,3-dihydropyrazino[1,2-a]indole-1,4-dione derivatives as EGFR and BRAF V600E dual inhibitors with potent antiproliferative and antioxidant activities. Bioorg Chem. 2022 Jan 19;120:105616.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
B-Raf; EGFR/ErbB1/HER1
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