Aurora kinase-IN-1
Aurora kinase-IN-1 (Compound 9) is a potent inhibitor of aurora kinase. Aurora kinase-IN-1 upregulates the expression of G1 cell cycle inhibitory proteins including p21 and p27, and G1 progressive cyclin D1, and downregulates G1-to-S progressive cyclins, resulting in cell cycle arrest at the G1/S boundary. Aurora kinase-IN-1 also induces apoptosis. Aurora kinase-IN-1 is a lead compound for chemotherapeutic agents[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Aurora Kinase
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/aurora-kinase-in-1.html
Solubility
10 mM in DMSO
Smiles
CCOC(/C(C1=O)=C/NC2=NC(C3=CC=C(C(OC)=C3)OC)=CC(C4=CC=C(C=C4)Br)=N2)OC5=C1C=C(Br)C=C5
Molecular Formula
C30H25Br2N3O5
Molecular Weight
667.34
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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