DENV-IN-4

DENV-IN-4 is a potent DENV inhibitor (DENV EC50=4.79 μM, Vero CC50>100 μM, SI>20.9) . DENV-IN-4 can inhibit the expression level of DENV2 with concentration-dependence and reduce RNA-dependent RNA polymerase (RdRp) enzymatic activity. DENV-IN-4 has antiviral effect[1].

Product Specifications

CAS Number

[2762302-75-8]

UNSPSC

12352005

Target

DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/denv-in-4.html

Solubility

10 mM in DMSO

Smiles

O=C1[C@@](CC2=CC=CC=C23)([H])N3[C@](C4=CC=C(C=C4)O[Si](C)(C)C(C)(C)C)([H])N1NC5=CC=C(C=C5)[N+]([O-])=O

Molecular Formula

C28H32N4O4Si

Molecular Weight

516.66

References & Citations

[1]Qian W, et al. Design, synthesis, discovery and SAR of the fused tricyclic derivatives of indoline and imidazolidinone against DENV replication and infection [published online ahead of print, 2022 Jan 24]. Bioorg Chem. 2022;120:105639.