M24
Product Specifications
UNSPSC Description
M24 is a Mcl-1 selective inhibitor. M24 exhibits good binding affinity against Mcl-1 with Ki value of 0.33 μM. M24 exhibits good anti-proliferative activity and induce apoptosis in HepG2 cells[1].
Target Antigen
Bcl-2 Family
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/m24.html
Solubility
10 mM in DMSO
Smiles
CC1=CC(OCCOC2=CC=C(C=C2)CN3CC(N(C3=O)CC(NC(C(NS(=O)(C4=CC([N+]([O-])=O)=C(C=C4)Cl)=O)=O)CC5=CC=C(C=C5)OCC6=CC=C(C=C6)Cl)=O)=O)=CC(C)=C1Cl
Molecular Weight
953.24
References & Citations
[1]Xiao Liang, et al. Design, synthesis and biological evaluation of hydantoin derivatives as Mcl-1 selective inhibitors. Bioorg Chem. 2022 Apr;121:105643.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-115928/M24-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-115928/
Clinical Information
No Development Reported
CAS Number
2761947-05-9
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