BRD4 Inhibitor-16

BRD4 Inhibitor-16 (Compound 4) is a potent inhibitor of bromodomain 4 (BRD4) . Overexpression of bromodomain 4 (BRD4) is closely correlated with a variety of human cancers by regulating the histone post-translational modifications. BRD4 Inhibitor-16 represents a useful tool for explorative studies of BRD4 inhibition, such as an improved understanding of BRD4 inhibitor release-related information[1].

Product Specifications

UNSPSC

12352005

Target

Epigenetic Reader Domain

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/brd4-inhibitor-16.html

Solubility

10 mM in DMSO

Smiles

CC1=NOC(C)=C1C2=CC=C3C(C(N(C(N3C)=O)CC(NCCNS(=O)(C4=C5C=CC=C6C(N(C(C(C=C4)=C65)=O)CCN7CCOCC7)=O)=O)=O)C8=CC=CC=C8)=C2

Molecular Formula

C42H43N7O8S

Molecular Weight

805.90

References & Citations

[1]Zhang H, et al. Activatable fluorescence molecular imaging and anti-tumor effects investigation of GSH-sensitive BRD4 ligands [published online ahead of print, 2022 Jan 25]. Bioorg Chem. 2022;120:105636.