Anti-inflammatory agent 8

Anti-inflammatory agent 8 (compound 13) is a tilomisole-based benzimidazothiazole derivative. Anti-inflammatory agent 8 expresses activity on COX-2 enzyme more than COX-1 with an IC50 of 0.09 nM. Anti-inflammatory agent 8 is orally active[1].

Product Specifications

CAS Number

1103920-19-9

UNSPSC

12352005

Target

COX

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/anti-inflammatory-agent-8.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=C(C)N2C3=CC=CC=C3N=C2S1)NNC(NC4=CC=CC=C4)=S

Molecular Formula

C18H15N5OS2

Molecular Weight

381.47

References & Citations

[1] Darwish SA, et al. New tilomisole-based benzimidazothiazole derivatives as anti-inflammatory agents: Synthesis, in vivo, in vitro evaluation, and in silico studies [published online ahead of print, 2022 Jan 29]. Bioorg Chem. 2022;120:105644.