NOS-IN-2

NOS-IN-2 (Compound 4i) is a potent, selective, imidamide derived NOS inhibitor with an IC50 against iNOS of 20 μM, without inhibiting eNOS. NOS-IN-2 has little toxicity and can be used for studying inflammatory disorders[1].

Product Specifications

CAS Number

[2766146-79-4]

UNSPSC

12352005

Target

NO Synthase

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/nos-in-2.html

Solubility

10 mM in DMSO

Smiles

COC1=CC=C(C(C(CCNC(C2=CC=C(C=C2)C(F)(F)F)=N)O)=C1)N

Molecular Formula

C18H20F3N3O2

Molecular Weight

367.37

References & Citations

[1]Fabio Arias, et al. Synthesis, bioevaluation and docking studies of new imidamide derivatives as nitric oxide synthase inhibitors. Bioorg Med Chem. 2021 Aug 15;44:116294.