K20

K20 is a potent and selective KRas G12C inhibitor with an IC50 of 1.16 μM. K20 shows anticancer activity in H358 cells (IC50= 0.78 μM) . K20 decreases the levels of phosphorylated Erk and leads to cancer cell apoptosis. K20 suppresses NCI-H358 tumor growth with a TGI of 41% without causing obvious toxicity[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; ERK; Ras

Type

Reference compound

Related Pathways

Apoptosis; GPCR/G Protein; MAPK/ERK Pathway; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/k20.html

Solubility

10 mM in DMSO

Smiles

C=C(C(N1CCN([C@@H](C1)C)C2=NC=NC3=C(C(C4=CC(Cl)=CC=C4OC)=C(C=C23)Cl)F)=O)C(F)(F)F

Molecular Formula

C24H20Cl2F4N4O2

Molecular Weight

543.34

References & Citations

[1]Zhao H, et al. Discovery of ARS-1620 analogs as KRas G12C inhibitors with high in vivo antitumor activity. Bioorg Chem. 2022, 121:105652.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

K-Ras

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