FLT3/CDK4-IN-1

FLT3/CDK4-IN-1 is a potent, high selective and orally active FLT3/CDK4 dual inhibitor (IC50=11 and 7 nM for FLT3 and CDK4, respectively) . FLT3/CDK4-IN-1 has antiproliferative activities against certain cancer cells. FLT3/CDK4-IN-1 has good antitumor effect in vivo[1].

Product Specifications

CAS Number

[2762296-44-4]

UNSPSC

12352005

Target

CDK; FLT3

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/flt3-cdk4-in-1.html

Solubility

10 mM in DMSO

Smiles

CC(N1N=CC2=NC=C(C3=NC(NC4=CC=C(N5CCN(CC)CC5)C(F)=C4)=NC=C3F)C=C21)C

Molecular Formula

C25H28F2N8

Molecular Weight

478.54

References & Citations

[1]Li X, et al. Synthesis and biological evaluation of 6- (pyrimidin-4-yl) -1H-pyrazolo[4,3-b]pyridine derivatives as novel dual FLT3/CDK4 inhibitors. Bioorg Chem. 2022;121:105669.