FGFR4-IN-7
FGFR4-IN-7 (Compound C3) is a covalent reversible FGFR4 inhibitor with an IC50 value of 0.42 μM. FGFR4-IN-7 induces apoptosis via the FGFR4 signaling pathway blockage. FGFR4-IN-7 can be used for the research of hepatocellular carcinoma (HCC) [1].
Product Specifications
CAS Number
2765046-07-7
UNSPSC
12352005
Target
Apoptosis; FGFR
Type
Reference compound
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fgfr4-in-7.html
Solubility
10 mM in DMSO
Smiles
COC1=CC(OC)=C(C(C2=CC3=CN=C(N=C3C=C2)NCCCNC(/C(C#N)=C/C4CC4)=O)=C1Cl)Cl
Molecular Formula
C26H25Cl2N5O3
Molecular Weight
526.41
References & Citations
[1]Wenwen Nie, et al. Design, synthesis, and biological evaluation of quinazoline derivatives with covalent reversible warheads as potential FGFR4 inhibitors. Bioorg Chem. 2022 Apr;121:105673.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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