MIF2-IN-1
MIF2-IN-1 (compound 5d) is a potent inhibitor of MIF2 tautomerase with an IC50 of 1.0 μM. MIF2-IN-1 suppresses the proliferation of non-small cell lung cancer cells by the induction of cell cycle arrest via deactivation of the MAPK pathway. MIF2-IN-1 has the potential for the research of cancer diseases[1].
Product Specifications
CAS Number
2917525-79-0
UNSPSC
12352005
Target
Macrophage migration inhibitory factor (MIF)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mif2-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=C(C2=O)C(C)=C(C3=CC(C(F)(F)F)=CC=C3)S1)N2[C@H](C)C4=C5C(C=CC=C5)=CC=C4
Molecular Formula
C26H19F3N2O2S
Molecular Weight
480.50
References & Citations
[1]Xiao Z, et al. Thieno[2,3-d]pyrimidine-2,4 (1H,3H) -dione Derivative Inhibits d-Dopachrome Tautomerase Activity and Suppresses the Proliferation of Non-Small Cell Lung Cancer Cells. J Med Chem. 2022 Feb 10;65 (3) :2059-2077.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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