Folate-MS432
Folate-MS432, a PROTAC, is capable of degrading MEKs in a folate receptor-dependent manner in cancer cells.
Product Specifications
CAS Number
2769735-56-8
UNSPSC
12352005
Target
PROTACs
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/folate-ms432.html
Solubility
10 mM in DMSO
Smiles
O=C([C@H]1N(C([C@H](C(C)(C)C)NC(CCCCCCCCCCNCCCONC(C2=CC=C(F)C(F)=C2NC3=CC=C(I)C=C3F)=O)=O)=O)C[C@H](OC(CCCCN4C=C(CNC(CC[C@H](NC(C5=CC=C(C=C5)NCC6=CN=C7NC(N)=NC(C7=N6)=O)=O)C(O)=O)=O)N=N4)=O)C1)N[C@H](C8=CC=C(C9=C(C)N=CS9)C=C8)C
Molecular Formula
C77H94F3IN18O12S
Molecular Weight
1679.65
References & Citations
[1]Liu J, et al. Cancer Selective Target Degradation by Folate-Caged PROTACs. J Am Chem Soc. 2021 May 19;143 (19) :7380-7387.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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