Ap44mSe

Ap44mSe is a selenosemicarbazone that effectively depletes cellular Fe, resulting in transferrin receptor-1 up-regulation, ferritin down-regulation, and increased expression of the potent metastasis suppressor, N-myc downstream regulated gene-1. Ap44mSe forms redox active Cu complexes that target the lysosome to induce lysosomal membrane permeabilization[1].

Product Specifications

CAS Number

[79514-49-1]

UNSPSC

12352005

Target

Others

Type

Reference compound

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ap44mse.html

Solubility

10 mM in DMSO

Smiles

C/C(C1=NC=CC=C1)=N\NC(N(C)C)=[Se]

Molecular Formula

C10H14N4Se

Molecular Weight

269.20

References & Citations

[1]Zaynab Al-Eisawi, et al. Novel Mechanism of Cytotoxicity for the Selective Selenosemicarbazone, 2-Acetylpyridine 4,4-Dimethyl-3-selenosemicarbazone (Ap44mSe) : Lysosomal Membrane Permeabilization. J Med Chem. 2016 Jan 14;59 (1) :294-312.