Ap44mSe
Product Specifications
UNSPSC Description
Ap44mSe is a selenosemicarbazone that effectively depletes cellular Fe, resulting in transferrin receptor-1 up-regulation, ferritin down-regulation, and increased expression of the potent metastasis suppressor, N-myc downstream regulated gene-1. Ap44mSe forms redox active Cu complexes that target the lysosome to induce lysosomal membrane permeabilization[1].
Target Antigen
Others
Type
Reference compound
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ap44mse.html
Solubility
10 mM in DMSO
Smiles
C/C(C1=NC=CC=C1)=N\NC(N(C)C)=[Se]
Molecular Weight
269.20
References & Citations
[1]Zaynab Al-Eisawi, et al. Novel Mechanism of Cytotoxicity for the Selective Selenosemicarbazone, 2-Acetylpyridine 4,4-Dimethyl-3-selenosemicarbazone (Ap44mSe): Lysosomal Membrane Permeabilization. J Med Chem. 2016 Jan 14;59(1):294-312.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-115832/Ap44mSe-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-115832/
Clinical Information
No Development Reported
CAS Number
79514-49-1
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