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3-Aminopropylphosphinic acid

3-Aminopropylphosphinic acid (3-APPA) is a phosphonic analog of GABA. 3-Aminopropylphosphinic acid is a potent, selective GABAB receptor agonist[1].

Product Specifications

CAS Number

103680-47-3

Product Name Alternative

3-APPA; CGP 27492; CGA 147823

UNSPSC

12352211

Target

GABA Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/3-aminopropylphosphinic-acid.html

Solubility

10 mM in H2O

Smiles

O=P(CCCN)O

Molecular Formula

C3H10NO2P

Molecular Weight

123.09

References & Citations

[1]Luzzi S, Franchi-Micheli S, Ciuffi M, Pajani A, Zilletti L. GABA-related activities of amino phosphonic acids on guinea-pig ileum longitudinal muscle. J Auton Pharmacol. 1986 Sep;6 (3) :163-9.|[2]Hills JM, Dingsdale RA, Parsons ME, Dolle RE, Howson W. 3-Aminopropylphosphinic acid--a potent, selective GABAB receptor agonist in the guinea-pig ileum and rat anococcygeus muscle. Br J Pharmacol. 1989 Aug;97 (4) :1292-6.|[3]Chapman RW, Danko G, Rizzo C, Egan RW, Mauser PJ, Kreutner W. Prejunctional GABA-B inhibition of cholinergic, neurally-mediated airway contractions in guinea-pigs. Pulm Pharmacol. 1991;4 (4) :218-24.|[4]Cho Youn-Ki, et al. 3-Aminopropyl dihydrogen phosphate (3-APPA; 3-aminopropane phosphoric acid) ; a novel anti-aging substance. Journal of Investigative Dermatology, vol. 4, no. 106, 2015, p. 895.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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