3-Aminopropylphosphinic acid
3-Aminopropylphosphinic acid (3-APPA) is a phosphonic analog of GABA. 3-Aminopropylphosphinic acid is a potent, selective GABAB receptor agonist[1].
Product Specifications
CAS Number
103680-47-3
Product Name Alternative
3-APPA; CGP 27492; CGA 147823
UNSPSC
12352211
Target
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/3-aminopropylphosphinic-acid.html
Solubility
10 mM in H2O
Smiles
O=P(CCCN)O
Molecular Formula
C3H10NO2P
Molecular Weight
123.09
References & Citations
[1]Luzzi S, Franchi-Micheli S, Ciuffi M, Pajani A, Zilletti L. GABA-related activities of amino phosphonic acids on guinea-pig ileum longitudinal muscle. J Auton Pharmacol. 1986 Sep;6 (3) :163-9.|[2]Hills JM, Dingsdale RA, Parsons ME, Dolle RE, Howson W. 3-Aminopropylphosphinic acid--a potent, selective GABAB receptor agonist in the guinea-pig ileum and rat anococcygeus muscle. Br J Pharmacol. 1989 Aug;97 (4) :1292-6.|[3]Chapman RW, Danko G, Rizzo C, Egan RW, Mauser PJ, Kreutner W. Prejunctional GABA-B inhibition of cholinergic, neurally-mediated airway contractions in guinea-pigs. Pulm Pharmacol. 1991;4 (4) :218-24.|[4]Cho Youn-Ki, et al. 3-Aminopropyl dihydrogen phosphate (3-APPA; 3-aminopropane phosphoric acid) ; a novel anti-aging substance. Journal of Investigative Dermatology, vol. 4, no. 106, 2015, p. 895.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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