Thio-ITP
Product Specifications
UNSPSC Description
Thio-ITP (6-Thioinosine 5′-triphosphate) is an RNA polymerase activity competitive inhibitor. Thio-ITP has a high apparent affinity for the polymerases (RNA polymerase I Ki: 40.9 μM; RNA polymerase II Ki: 38.0 μM)[1].
Target Antigen
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/thio-itp.html
Solubility
10 mM in DMSO
Smiles
O[C@H]1[C@](O[C@@H]([C@H]1O)COP(OP(OP(O)(O)=O)(O)=O)(O)=O)([H])N2C3=C(C(N=CN3)=S)N=C2
Molecular Weight
524.23
References & Citations
[1]Kawahata RT, Chuang LF, Holmberg CA, Osburn BI, Chuang RY. Inhibition of human lymphoma DNA-dependent RNA polymerase activity by 6-mercaptopurine ribonucleoside triphosphate. Cancer Res. 1983 Aug;43(8):3655-9.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-115755/Thio-ITP-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-115755/
Clinical Information
No Development Reported
CAS Number
27652-34-2
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