S- (N-PhenethylthiocarbaMoyl) -L-cysteine
S- (N-PhenethylthiocarbaMoyl) -L-cysteine (PEITC-Cys), an anticarcinogenic agent, has antileukemic activity. S- (N-PhenethylthiocarbaMoyl) -L-cysteine inhibits DNA synthesis in HL60 cells[1]. S- (N-PhenethylthiocarbaMoyl) -L-cysteine is a P450 inhibitor[2].
Product Specifications
CAS Number
53330-02-2
Product Name Alternative
PEITC-Cys
UNSPSC
12352005
Target
Cytochrome P450; DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/s-n-phenethylthiocarbamoyl-l-cysteine.html
Solubility
10 mM in DMSO
Smiles
N[C@@H](CSC(NCCC1=CC=CC=C1)=S)C(O)=O
Molecular Formula
C12H16N2O2S2
Molecular Weight
284.40
References & Citations
[1]Adesida A, Edwards LG, Thornalley PJ. Inhibition of human leukaemia 60 cell growth by mercapturic acid metabolites of phenylethyl isothiocyanate. Food Chem Toxicol. 1996 Apr;34 (4) :385-92.|[2]Conaway CC, et al. Decomposition rates of isothiocyanate conjugates determine their activity as inhibitors of cytochrome p450 enzymes. Chem Res Toxicol. 2001 Sep;14 (9) :1170-6.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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