Calpain Inhibitor-1
Calpain Inhibitor-1 (compound 36) is a potent and selective cysteine protease calpain 1 (Cal1) inhibitor (IC50=100 nM; Ki=2.89 μM) [1].
Product Specifications
CAS Number
[1448429-06-8]
UNSPSC
12352005
Target
Proteasome
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/calpain-inhibitor-1.html
Solubility
10 mM in DMSO
Smiles
FC(C=C1)=CC=C1N(N=N2)C=C2CNC([C@H](CC3=CSC=N3)NC([C@@H]4[C@H](O4)C(O)=O)=O)=O
Molecular Formula
C19H17FN6O5S
Molecular Weight
460.44
References & Citations
[1]Schiefer IT, Tapadar S, Litosh V, et al. Design, synthesis, and optimization of novel epoxide incorporating peptidomimetics as selective calpain inhibitors. J Med Chem. 2013;56 (15) :6054-6068.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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