Nω-allyl-L-arginine

Nω-allyl-L-arginine is a competitive and reversible inhibitor of bovine brain nitric oxide synthase (nNOS) . Nω-allyl-L-arginine can inactivate nNOS in a time-dependent manner. Nω-allyl-L-arginine also is a substrate, producing L-arginine, acrolein, and H2O[1][2].

Product Specifications

CAS Number

[139461-37-3]

UNSPSC

12352211

Target

NO Synthase

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/nω-allyl-l-arginine.html

Solubility

10 mM in DMSO

Smiles

N[C@@H](CCCNC(NCC=C)=N)C(O)=O

Molecular Formula

C9H18N4O2

Molecular Weight

214.26

References & Citations

[1]Zhang HQ, et, al. Mechanism of Inactivation of Neuronal Nitric Oxide Synthase by Nω-Allyl-l-Arginine. J. Am. Chem. Soc. 1997, 119, 45, 10888-10902.|[2]Hah JM, et, al. Deuterium isotope effects and product studies for the oxidation of N (omega) -allyl-L-arginine and N (omega) -allyl-N (omega) -hydroxy-L-arginine by neuronal nitric oxide synthase. Bioorg Med Chem. 2000 Aug;8 (8) :1931-6.