Mant-GTPγS
Mant-GTPγS, a GTP mimetic, is a potent competitive adenylyl cyclase (AC) inhibitor. Mant-GTPγS is a potent YdeH inhibitor[1][2][3].
Product Specifications
CAS Number
136749-24-1
UNSPSC
12352005
Target
Adenylate Cyclase
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/mant-gtpγs.html
Concentration
10 mM * 10 μL in Water
Purity
93.0
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=CC=C1NC)[.O=C2C(N=CN3[C@H]4[C@H](O[R])[C@H](O[R])[C@@H](COP(OP(OP(O)(O)=S)(O)=O)(O)=O)O4)=C3N=C(N)N2.[or].[H]
Molecular Formula
C18H23N6O14P3S
Molecular Weight
672.39
References & Citations
[1]Andreas Gille, et al. 2' (3') -O- (N-methylanthraniloyl) -substituted GTP analogs: a novel class of potent competitive adenylyl cyclase inhibitors. J Biol Chem. 2003 Apr 11;278 (15) :12672-9.|[2]Tomoharu Kanie, et al. The CEP19-RABL2 GTPase Complex Binds IFT-B to Initiate Intraflagellar Transport at the Ciliary Base. Dev Cell. 2017 Jul 10;42 (1) :22-36.e12.|[3]Christian Spangler, et al. Interaction of the diguanylate cyclase YdeH of Escherichia coli with 2', (3') -substituted purine and pyrimidine nucleotides. J Pharmacol Exp Ther. 2011 Jan;336 (1) :234-41.
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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