L-threo-PPMP
L-threo-PPMP is a GlcT (UDP-Glc: Ceramide β1,1glucosyltransferase) inhibitor. L-threo-PPMP inhibits glycosphingolipid biosynthesis and induces apoptosis. L-threo-PPMP has anti-cancer activity[1].
Product Specifications
CAS Number
[207278-87-3]
UNSPSC
12352005
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/l-threo-ppmp.html
Solubility
10 mM in DMSO
Smiles
CCCCCCCCCCCCCCCC(N[C@@H](CN1CCOCC1)[C@@H](O)C2=CC=CC=C2)=O
Molecular Formula
C29H50N2O3
Molecular Weight
474.72
References & Citations
[1]Subhash Basu, et al. Apoptosis of human carcinoma cells in the presence of inhibitors of glycosphingolipid biosynthesis: I. Treatment of Colo-205 and SKBR3 cells with isomers of PDMP and PPMP. Glycoconj J. 2004;20 (3) :157-68.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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