L-threo-PPMP

L-threo-PPMP is a GlcT (UDP-Glc: Ceramide β1,1glucosyltransferase) inhibitor. L-threo-PPMP inhibits glycosphingolipid biosynthesis and induces apoptosis. L-threo-PPMP has anti-cancer activity[1].

Product Specifications

CAS Number

[207278-87-3]

UNSPSC

12352005

Target

Apoptosis

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/l-threo-ppmp.html

Solubility

10 mM in DMSO

Smiles

CCCCCCCCCCCCCCCC(N[C@@H](CN1CCOCC1)[C@@H](O)C2=CC=CC=C2)=O

Molecular Formula

C29H50N2O3

Molecular Weight

474.72

References & Citations

[1]Subhash Basu, et al. Apoptosis of human carcinoma cells in the presence of inhibitors of glycosphingolipid biosynthesis: I. Treatment of Colo-205 and SKBR3 cells with isomers of PDMP and PPMP. Glycoconj J. 2004;20 (3) :157-68.