Phenylpyropene C
Phenylpyropene C (S14-95), a JAK/STAT pathway inhibitor, can inhibit IFN-γ mediated expression of the reporter gene (IC50=5.4~10.8 μM) . Phenylpyropene C also is an inhibitor of acyl-CoA, with an IC50 of 16.0 μM[1][2].
Product Specifications
CAS Number
419532-92-6
Product Name Alternative
S14-95
UNSPSC
12352005
Target
Acyltransferase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/phenylpyropene-c.html
Solubility
10 mM in DMSO
Smiles
C[C@@]12[C@]3([H])[C@](OC4=C(C(OC(C5=CC=CC=C5)=C4)=O)C3)(CC[C@@]1([H])C(C)([C@H](CC2)OC(C)=O)C)C
Molecular Formula
C28H34O5
Molecular Weight
450.57
References & Citations
[1]Rho MC, et, al. Phenylpyropene C, a new inhibitor of acyl-CoA: cholesterol acyltransferase produced by Penicillium griseofulvum F1959. J Antibiot (Tokyo) . 2002 Feb;55 (2) :211-4.|[2]Erkel G, et, al. S14-95, a novel inhibitor of the JAK/STAT pathway from a Penicillium species. J Antibiot (Tokyo) . 2003 Apr;56 (4) :337-43.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ACAT
Frequently Asked Questions
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