Phenylpyropene C

Phenylpyropene C (S14-95), a JAK/STAT pathway inhibitor, can inhibit IFN-γ mediated expression of the reporter gene (IC50=5.4~10.8 μM) . Phenylpyropene C also is an inhibitor of acyl-CoA, with an IC50 of 16.0 μM[1][2].

Product Specifications

CAS Number

[419532-92-6]

Product Name Alternative

S14-95

UNSPSC

12352005

Target

Acyltransferase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/phenylpyropene-c.html

Solubility

10 mM in DMSO

Smiles

C[C@@]12[C@]3([H])[C@](OC4=C(C(OC(C5=CC=CC=C5)=C4)=O)C3)(CC[C@@]1([H])C(C)([C@H](CC2)OC(C)=O)C)C

Molecular Formula

C28H34O5

Molecular Weight

450.57

References & Citations

[1]Rho MC, et, al. Phenylpyropene C, a new inhibitor of acyl-CoA: cholesterol acyltransferase produced by Penicillium griseofulvum F1959. J Antibiot (Tokyo) . 2002 Feb;55 (2) :211-4.|[2]Erkel G, et, al. S14-95, a novel inhibitor of the JAK/STAT pathway from a Penicillium species. J Antibiot (Tokyo) . 2003 Apr;56 (4) :337-43.