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BET-IN-1

BET-IN-1 is a potent BET inhibitor that has excellent brain penetration and reasonable metabolic stability.

Product Specifications

CAS Number

2727161-43-3

UNSPSC

12352005

Target

Epigenetic Reader Domain

Type

Reference compound

Related Pathways

Epigenetics

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/bet-in-1-1.html

Solubility

10 mM in DMSO

Smiles

ClC1=CC=C(C2=N[C@H](C3=NN=C(N3C4=C2C(C)=C(S4)C)C)CC(OCCOCCF)=O)C=C1

Molecular Formula

C23H24ClFN4O3S

Molecular Weight

490.98

References & Citations

[1]Bai P, et al. Design, Synthesis, and Evaluation of Thienodiazepine Derivatives as Positron Emission Tomography Imaging Probes for Bromodomain and Extra-Terminal Domain Family Proteins. J Med Chem. 2021 Oct 14;64 (19) :14745-14756.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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