FPPQ
FPPQ is a dual-acting 5-HT3 (Ki = 0.9 nM) and 5-HT6 (Ki = 3 nM) receptor antagonist with antipsychotic and procognitive properties.
Product Specifications
CAS Number
1648745-46-3
UNSPSC
12352005
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/fppq.html
Solubility
10 mM in DMSO
Smiles
O=S(N1C=CC2=C1C3=CC=CC=C3N=C2N4CCNCC4)(C5=CC(F)=CC=C5)=O
Molecular Formula
C21H19FN4O2S
Molecular Weight
410.46
References & Citations
[1]Zajdel P, et al. Structure-Based Design and Optimization of FPPQ, a Dual-Acting 5-HT3 and 5-HT6 Receptor Antagonist with Antipsychotic and Procognitive Properties. J Med Chem. 2021 Sep 23;64 (18) :13279-13298.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT6 Receptor
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