R121919 (hydrochloride)
Product Specifications
UNSPSC Description
R121919 (NBI30775) hydrochloride is a potent and selective CRF1R antagonist with a Ki of 2 to 5 nM. R121919 hydrochloride has antidepressant and anxiolytic effects. R121919 hydrochloride alleviates defensive withdrawal in rats[1][2][3].
Target Antigen
CRFR
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/r121919-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
CCCN(CCC)C1=CC(C)=NC2=C(C3=C(C)C=C(N(C)C)N=C3)C(C)=NN12.[H]Cl
Molecular Weight
416.99
References & Citations
[1]Gutman DA, et al. Behavioral effects of the CRF1 recepator antagonist R121919 in rats selectively bred for high and low activity in the swim test. Psychoneuroendocrinology. 2008 Sep;33(8):1093-101.|[2]Gutman DA, et al. The corticotropin-releasing factor1 receptor antagonist R121919 attenuates the behavioral and endocrine responses to stress. J Pharmacol Exp Ther. 2003 Feb;304(2):874-80.|[3]Post A, et al. Identification of molecules potentially involved in mediating the in vivo actions of the corticotropin-releasing hormone receptor 1 antagonist, NBI30775 (R121919). Psychopharmacology (Berl). 2005 Jun;180(1):150-8.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-115645/R121919-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-115645/
Clinical Information
No Development Reported
CAS Number
195055-66-4
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS6324029-01 0.1 mL
NCAM2, ID (NCAM2, NCAM21, Neural cell adhesion molecule 2) (MaxLight 490)
Ask
View Details MBS6324029-02 5x 0.1 mL
NCAM2, ID (NCAM2, NCAM21, Neural cell adhesion molecule 2) (MaxLight 490)
Ask
View Details 
