FF-10502
FF-10502, a structural analog of Gemcitabine, is a pyrimidine nucleoside antimetabolite. FF-10502 inhibits DNA polymerase α and β. FF-10502 shows beneficial anticancer activity via a mechanism of action on dormant cells[1].
Product Specifications
CAS Number
[184302-49-6]
UNSPSC
12352005
Target
DNA/RNA Synthesis; Nucleoside Antimetabolite/Analog
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ff-10502.html
Solubility
10 mM in DMSO
Smiles
O=C1N([C@@H]2S[C@H](CO)[C@@H](O)[C@@H]2F)C=CC(N)=N1
Molecular Formula
C9H12FN3O3S
Molecular Weight
261.27
References & Citations
[1]Shinji Mima, et al. FF-10502, an Antimetabolite with Novel Activity on Dormant Cells, Is Superior to Gemcitabine for Targeting Pancreatic Cancer Cells. J Pharmacol Exp Ther. 2018 Jul;366 (1) :125-135.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-115528/FF-10502-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-115528/
Scientific Category
Reference compound1
Clinical Information
Phase 2
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